Abstract
A series of variably substituted derivatives of lignan lactones and diols were prepared using tandem conjugate addition reaction as a key step. These theoretical precursors of the mammalian lignans enterolactone 1 and enterodiol 3 are moderate or weak inhibitors of human aromatase activity.
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemical synthesis
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4-Butyrolactone / chemistry
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4-Butyrolactone / pharmacology
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Aromatase Inhibitors*
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Catechols / chemical synthesis*
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Catechols / pharmacology*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Humans
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Lignans / chemistry
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Phenols / chemical synthesis*
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Phenols / pharmacology*
Substances
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3'-demethoxysecoisolariciresinol
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3-demethoxy-3'-O-demethylmatairesinol
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Aromatase Inhibitors
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Catechols
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Enzyme Inhibitors
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Lignans
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Phenols
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2,3-bis(3'-hydroxybenzyl)butane-1,4-diol
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4-Butyrolactone
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2,3-bis(3'-hydroxybenzyl)butyrolactone