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BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics.
Haematologica. 2024 Apr 1;109(4):1253-1258. doi: 10.3324/haematol.2023.283060.
Haematologica. 2024.
PMID: 37881837
Free PMC article.
No abstract available.
BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics.
Villalobos-Ortiz M, Ryan J, Mashaka TN, Opferman JT, Letai A.
Villalobos-Ortiz M, et al.
Cell Death Differ. 2020 Mar;27(3):999-1007. doi: 10.1038/s41418-019-0391-9. Epub 2019 Jul 22.
Cell Death Differ. 2020.
PMID: 31332296
Free PMC article.
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Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL.
Bojarczuk K, Wienand K, Ryan JA, Chen L, Villalobos-Ortiz M, Mandato E, Stachura J, Letai A, Lawton LN, Chapuy B, Shipp MA.
Bojarczuk K, et al. Among authors: villalobos ortiz m.
Blood. 2019 Jan 3;133(1):70-80. doi: 10.1182/blood-2018-08-872465. Epub 2018 Oct 15.
Blood. 2019.
PMID: 30322870
Free PMC article.
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Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
Replogle JM, Zhou W, Amaro AE, McFarland JM, Villalobos-Ortiz M, Ryan J, Letai A, Yilmaz O, Sheltzer J, Lippard SJ, Ben-David U, Amon A.
Replogle JM, et al. Among authors: villalobos ortiz m.
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30566-30576. doi: 10.1073/pnas.2009506117. Epub 2020 Nov 17.
Proc Natl Acad Sci U S A. 2020.
PMID: 33203674
Free PMC article.
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Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling.
Seyfried F, Demir S, Hörl RL, Stirnweiß FU, Ryan J, Scheffold A, Villalobos-Ortiz M, Boldrin E, Zinngrebe J, Enzenmüller S, Jenni S, Tsai YC, Bornhauser B, Fürstberger A, Kraus JM, Kestler HA, Bourquin JP, Stilgenbauer S, Letai A, Debatin KM, Meyer LH.
Seyfried F, et al. Among authors: villalobos ortiz m.
Cell Death Dis. 2019 Jul 29;10(8):571. doi: 10.1038/s41419-019-1801-0.
Cell Death Dis. 2019.
PMID: 31358732
Free PMC article.
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