BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics

Affiliations

• ¹ Bone Marrow Transplantation Center of the First Affiliated Hospital and Institute of Hematology and Department of Immunology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215.
• ² Novartis Institute of Biomedical Research, Oncology Drug Discovery, Cambridge, MA 02139.
• ³ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA ; Harvard Medical School, Boston, MA 02215.
• ⁴ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA ; Harvard Medical School, Boston, MA 02215. Anthony_Letai@dfci.harvard.edu.