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"Stripe" transcription factors provide accessibility to co-binding partners in mammalian genomes.
Zhao Y, Vartak SV, Conte A, Wang X, Garcia DA, Stevens E, Kyoung Jung S, Kieffer-Kwon KR, Vian L, Stodola T, Moris F, Chopp L, Preite S, Schwartzberg PL, Kulinski JM, Olivera A, Harly C, Bhandoola A, Heuston EF, Bodine DM, Urrutia R, Upadhyaya A, Weirauch MT, Hager G, Casellas R. Zhao Y, et al. Among authors: vartak sv. Mol Cell. 2022 Sep 15;82(18):3398-3411.e11. doi: 10.1016/j.molcel.2022.06.029. Epub 2022 Jul 20. Mol Cell. 2022. PMID: 35863348 Free PMC article.
SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation.
Gopalakrishnan V, Sharma S, Ray U, Manjunath M, Lakshmanan D, Vartak SV, Gopinatha VK, Srivastava M, Kempegowda M, Choudhary B, Raghavan SC. Gopalakrishnan V, et al. Among authors: vartak sv. Mol Carcinog. 2021 Sep;60(9):627-643. doi: 10.1002/mc.23329. Epub 2021 Jun 30. Mol Carcinog. 2021. PMID: 34192388
Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner.
Vartak SV, Swarup HA, Gopalakrishnan V, Gopinatha VK, Ropars V, Nambiar M, John F, Kothanahally SKS, Kumari R, Kumari N, Ray U, Radha G, Dinesh D, Pandey M, Ananda H, Karki SS, Srivastava M, Charbonnier JB, Choudhary B, Mantelingu K, Raghavan SC. Vartak SV, et al. FEBS J. 2018 Nov;285(21):3959-3976. doi: 10.1111/febs.14661. Epub 2018 Oct 8. FEBS J. 2018. PMID: 30230716 Free article.
14 results