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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O'Brien R, Hak E, Baak BN, Pfeiffer R, Baloni P, Mohmoudiandehkordi S, Nho K, Kaddurah-Daouk R, Bennett DA, Gadalla SM, Thambisetty M. Varma VR, et al. Among authors: varma s. PLoS Med. 2021 May 27;18(5):e1003615. doi: 10.1371/journal.pmed.1003615. eCollection 2021 May. PLoS Med. 2021. PMID: 34043628 Free PMC article.
Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals.
Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, Riveros C, Moscato P, Griswold M, Sonntag D, Wahrheit J, Klavins K, Jonsson PV, Eiriksdottir G, Aspelund T, Launer LJ, Gudnason V, Legido Quigley C, Thambisetty M. Casanova R, et al. Among authors: varma s. Alzheimers Dement. 2016 Jul;12(7):815-22. doi: 10.1016/j.jalz.2015.12.008. Epub 2016 Jan 21. Alzheimers Dement. 2016. PMID: 26806385 Free PMC article.
Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. Varma VR, et al. Among authors: varma s. Mol Psychiatry. 2017 Jan;22(1):13-23. doi: 10.1038/mp.2016.206. Epub 2016 Nov 22. Mol Psychiatry. 2017. PMID: 27872486 Free PMC article.
Metabolic network failures in Alzheimer's disease: A biochemical road map.
Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MYR, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. Toledo JB, et al. Among authors: varma s. Alzheimers Dement. 2017 Sep;13(9):965-984. doi: 10.1016/j.jalz.2017.01.020. Epub 2017 Mar 22. Alzheimers Dement. 2017. PMID: 28341160 Free PMC article.
Evidence for brain glucose dysregulation in Alzheimer's disease.
An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M. An Y, et al. Among authors: varma s, varma vr. Alzheimers Dement. 2018 Mar;14(3):318-329. doi: 10.1016/j.jalz.2017.09.011. Epub 2017 Oct 19. Alzheimers Dement. 2018. PMID: 29055815 Free PMC article.
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M. Varma VR, et al. Among authors: varma s. PLoS Med. 2018 Jan 25;15(1):e1002482. doi: 10.1371/journal.pmed.1002482. eCollection 2018 Jan. PLoS Med. 2018. PMID: 29370177 Free PMC article.
Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.
Mahajan UV, Varma VR, Griswold ME, Blackshear CT, An Y, Oommen AM, Varma S, Troncoso JC, Pletnikova O, O'Brien R, Hohman TJ, Legido-Quigley C, Thambisetty M. Mahajan UV, et al. Among authors: varma s, varma vr. PLoS Med. 2020 Jan 24;17(1):e1003012. doi: 10.1371/journal.pmed.1003012. eCollection 2020 Jan. PLoS Med. 2020. PMID: 31978055 Free PMC article.
Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.
Mahajan UV, Varma VR, Griswold ME, Blackshear CT, An Y, Oommen AM, Varma S, Troncoso JC, Pletnikova O, O'Brien R, Hohman TJ, Legido-Quigley C, Thambisetty M. Mahajan UV, et al. Among authors: varma s, varma vr. PLoS Med. 2020 Oct 21;17(10):e1003439. doi: 10.1371/journal.pmed.1003439. eCollection 2020 Oct. PLoS Med. 2020. PMID: 33085665 Free PMC article.
1,755 results