Peril beyond the winner's curse: A small sample size is the bane of biomarker discovery

Alzheimers Dement. 2017 May;13(5):606-607. doi: 10.1016/j.jalz.2017.01.003. Epub 2017 Jan 21.

Authors

Madhav Thambisetty¹, Ramon Casanova², Sudhir Varma³, Cristina Legido Quigley⁴

Affiliations

¹ Laboratory of Behavioral Neuroscience Clinical and Translational Neuroscience Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Electronic address: thambisettym@mail.nih.gov.
² Wake Forest School of Medicine, Winston-Salem, NC, USA.
³ HiThru Analytics LLC, Laurel, MD, USA.
⁴ King's College, London, United Kingdom.

PMID: 28119051
DOI: 10.1016/j.jalz.2017.01.003

No abstract available

Publication types

Letter
Comment

MeSH terms

Aged
Biomarkers*
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Phospholipids*
Sample Size

Substances

Biomarkers
Phospholipids