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The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ.
Li X, Hernandez I, Koyuncu S, Kis B, Häggblad M, Lidemalm L, Abbas AA, Bendegúz S, Göblös A, Brautigam L, Lucas JJ, Carreras-Puigvert J, Hühn D, Pircs K, Vilchez D, Fernandez-Capetillo O. Li X, et al. Among authors: vilchez d. EBioMedicine. 2024 May 2;103:105124. doi: 10.1016/j.ebiom.2024.105124. Online ahead of print. EBioMedicine. 2024. PMID: 38701619 Free article.
In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation.
Llamas E, Koyuncu S, Lee HJ, Wehrmann M, Gutierrez-Garcia R, Dunken N, Charura N, Torres-Montilla S, Schlimgen E, Mandel AM, Theile EB, Grossbach J, Wagle P, Lackmann JW, Schermer B, Benzing T, Beyer A, Pulido P, Rodriguez-Concepcion M, Zuccaro A, Vilchez D. Llamas E, et al. Among authors: vilchez d. Nat Aging. 2023 Nov;3(11):1345-1357. doi: 10.1038/s43587-023-00502-1. Epub 2023 Oct 2. Nat Aging. 2023. PMID: 37783816 Free PMC article.
Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence.
Ruiz-Solaní N, Salguero-Linares J, Armengot L, Santos J, Pallarès I, van Midden KP, Phukkan UJ, Koyuncu S, Borràs-Bisa J, Li L, Popa C, Eisele F, Eisele-Bürger AM, Hill SM, Gutiérrez-Beltrán E, Nyström T, Valls M, Llamas E, Vilchez D, Klemenčič M, Ventura S, Coll NS. Ruiz-Solaní N, et al. Among authors: vilchez d. Plant Cell. 2023 Sep 1;35(9):3325-3344. doi: 10.1093/plcell/koad172. Plant Cell. 2023. PMID: 37401663 Free PMC article.
Experiences of insecurity among non-standard workers across different welfare states: A qualitative cross-country study.
Bosmans K, Vignola EF, Álvarez-López V, Julià M, Ahonen EQ, Bolíbar M, Gutiérrez-Zamora M, Ivarsson L, Kvart S, Muntaner C, O'Campo P, Ruiz ME, Vänerhagen K, Cuervo I, Davis L, Diaz I, Escrig-Piñol A, Gunn V, Lewchuk W, Östergren PO, Padrosa E, Vílchez D, Vives A, Vos M, Zaupa A, Bodin T, Baron SL. Bosmans K, et al. Among authors: vilchez d. Soc Sci Med. 2023 Jun;327:115970. doi: 10.1016/j.socscimed.2023.115970. Epub 2023 May 17. Soc Sci Med. 2023. PMID: 37210981 Free article.
A tale of two pathways: Regulation of proteostasis by UPRmt and MDPs.
Johns A, Higuchi-Sanabria R, Thorwald MA, Vilchez D. Johns A, et al. Among authors: vilchez d. Curr Opin Neurobiol. 2023 Feb;78:102673. doi: 10.1016/j.conb.2022.102673. Epub 2023 Jan 6. Curr Opin Neurobiol. 2023. PMID: 36621224 Free PMC article. Review.
63 results