The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Markus Wehrmann; David Vilchez

doi:10.3389/fimmu.2023.1303072

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Front Immunol. 2023 Nov 22:14:1303072. doi: 10.3389/fimmu.2023.1303072. eCollection 2023.

Authors

Markus Wehrmann^{1

2}, David Vilchez^{1

2

3

4}

Affiliations

¹ Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
² Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.
³ Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
⁴ Institute for Genetics, University of Cologne, Cologne, Germany.

Abstract

Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and manipulating ubiquitin (Ub)-dependent host processes during infection. The studies discussed here highlight the importance of DUB host-pathogen research and underscore the therapeutic potential of inhibiting pathogen-specific DUB activity to prevent infectious diseases.

Keywords: autophagy and apoptosis; deubiquitinating enzymes (DUBs); immune responses; infection mechanisms; ubiquitin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacteria
Deubiquitinating Enzymes
Humans
Parasites*
Ubiquitin

Substances

Deubiquitinating Enzymes
Ubiquitin

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Deutsche Forschungsgemeinschaft (DFG) (VI742/4-1 and Germany’s Excellence Strategy-CECAD, EXC 2030-390661388). MW received support by the Cologne Graduate School of Ageing Research.