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Palmitoylation couples insulin hypersecretion with β cell failure in diabetes.
Dong G, Adak S, Spyropoulos G, Zhang Q, Feng C, Yin L, Speck SL, Shyr Z, Morikawa S, Kitamura RA, Kathayat RS, Dickinson BC, Ng XW, Piston DW, Urano F, Remedi MS, Wei X, Semenkovich CF. Dong G, et al. Among authors: urano f. Cell Metab. 2023 Feb 7;35(2):332-344.e7. doi: 10.1016/j.cmet.2022.12.012. Epub 2023 Jan 11. Cell Metab. 2023. PMID: 36634673 Free PMC article.
GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.
Gorgogietas V, Rajaei B, Heeyoung C, Santacreu BJ, Marín-Cañas S, Salpea P, Sawatani T, Musuaya A, Arroyo MN, Moreno-Castro C, Benabdallah K, Demarez C, Toivonen S, Cosentino C, Pachera N, Lytrivi M, Cai Y, Carnel L, Brown C, Urano F, Marchetti P, Gilon P, Eizirik DL, Cnop M, Igoillo-Esteve M. Gorgogietas V, et al. Among authors: urano f. Diabetologia. 2023 Jul;66(7):1306-1321. doi: 10.1007/s00125-023-05905-8. Epub 2023 Mar 30. Diabetologia. 2023. PMID: 36995380 Free PMC article.
Genotype and Clinical Characteristics of Patients with Wolfram Syndrome and WFS1-related Disorders.
Lee EM, Verma M, Palaniappan N, Pope EM, Lee S, Blacher L, Neerumalla P, An W, Campbell T, Brown C, Hurst S, Marshall B, Hershey T, Nunes V, de Heredia ML, Urano F. Lee EM, et al. Among authors: urano f. medRxiv [Preprint]. 2023 Feb 16:2023.02.15.23284904. doi: 10.1101/2023.02.15.23284904. medRxiv. 2023. PMID: 36824811 Free PMC article. Updated. Preprint.
Extensive Hepatic Infarction due to Polycythemia Vera.
Furukawa K, Urano F, Okamura S, Kawashima H. Furukawa K, et al. Among authors: urano f. J Gastrointestin Liver Dis. 2024 Mar 29;33(1):18. doi: 10.15403/jgld-5379. J Gastrointestin Liver Dis. 2024. PMID: 38554424 Free article.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Kim Y, et al. Among authors: urano f. Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0. Nat Commun. 2023. PMID: 37838725 Free PMC article.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy.
Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Kim Y, et al. Among authors: urano f. bioRxiv [Preprint]. 2023 Jan 12:2023.01.10.523171. doi: 10.1101/2023.01.10.523171. bioRxiv. 2023. PMID: 36711449 Free PMC article. Updated. Preprint.
197 results