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Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model.
Brazel EB, Tan A, Neville SL, Iverson AR, Udagedara SR, Cunningham BA, Sikanyika M, De Oliveira DMP, Keller B, Bohlmann L, El-Deeb IM, Ganio K, Eijkelkamp BA, McEwan AG, von Itzstein M, Maher MJ, Walker MJ, Rosch JW, McDevitt CA. Brazel EB, et al. Among authors: udagedara sr. Cell Rep. 2022 Jan 11;38(2):110202. doi: 10.1016/j.celrep.2021.110202. Cell Rep. 2022. PMID: 35021083 Free PMC article.
Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus.
Monk IR, Shaikh N, Begg SL, Gajdiss M, Sharkey LKR, Lee JYH, Pidot SJ, Seemann T, Kuiper M, Winnen B, Hvorup R, Collins BM, Bierbaum G, Udagedara SR, Morey JR, Pulyani N, Howden BP, Maher MJ, McDevitt CA, King GF, Stinear TP. Monk IR, et al. Among authors: udagedara sr. Nat Commun. 2019 Jul 11;10(1):3067. doi: 10.1038/s41467-019-10932-4. Nat Commun. 2019. PMID: 31296851 Free PMC article.