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Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor.
Vidilaseris K, Kiriazis A, Turku A, Khattab A, Johansson NG, Leino TO, Kiuru PS, Boije Af Gennäs G, Meri S, Yli-Kauhaluoma J, Xhaard H, Goldman A. Vidilaseris K, et al. Among authors: turku a. Sci Adv. 2019 May 22;5(5):eaav7574. doi: 10.1126/sciadv.aav7574. eCollection 2019 May. Sci Adv. 2019. PMID: 31131322 Free PMC article.
Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment.
Johansson NG, Turku A, Vidilaseris K, Dreano L, Khattab A, Ayuso Pérez D, Wilkinson A, Zhang Y, Tamminen M, Grazhdankin E, Kiriazis A, Fishwick CWG, Meri S, Yli-Kauhaluoma J, Goldman A, Boije Af Gennäs G, Xhaard H. Johansson NG, et al. Among authors: turku a. ACS Med Chem Lett. 2020 Feb 17;11(4):605-610. doi: 10.1021/acsmedchemlett.9b00537. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292570 Free PMC article.
Azulene-based compounds for targeting orexin receptors.
Leino TO, Turku A, Yli-Kauhaluoma J, Kukkonen JP, Xhaard H, Wallén EAA. Leino TO, et al. Among authors: turku a. Eur J Med Chem. 2018 Sep 5;157:88-100. doi: 10.1016/j.ejmech.2018.07.040. Epub 2018 Jul 20. Eur J Med Chem. 2018. PMID: 30077889
Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.
Provenzani R, Tarvainen I, Brandoli G, Lempinen A, Artes S, Turku A, Jäntti MH, Talman V, Yli-Kauhaluoma J, Tuominen RK, Boije Af Gennäs G. Provenzani R, et al. Among authors: turku a. PLoS One. 2018 Apr 11;13(4):e0195668. doi: 10.1371/journal.pone.0195668. eCollection 2018. PLoS One. 2018. PMID: 29641588 Free PMC article.
21 results