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Beyond the cell factory: Homeostatic regulation of and by the UPRER.
Metcalf MG, Higuchi-Sanabria R, Garcia G, Tsui CK, Dillin A. Metcalf MG, et al. Among authors: tsui ck. Sci Adv. 2020 Jul 15;6(29):eabb9614. doi: 10.1126/sciadv.abb9614. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832649 Free PMC article. Review.
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
Moehle EA, Higuchi-Sanabria R, Tsui CK, Homentcovschi S, Tharp KM, Zhang H, Chi H, Joe L, de Los Rios Rogers M, Sahay A, Kelet N, Benitez C, Bar-Ziv R, Garcia G, Shen K, Frankino PA, Schinzel RT, Shalem O, Dillin A. Moehle EA, et al. Among authors: tsui ck. Sci Adv. 2021 Oct 29;7(44):eabj6818. doi: 10.1126/sciadv.abj6818. Epub 2021 Oct 29. Sci Adv. 2021. PMID: 34714674 Free PMC article.
Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span.
Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, Fan W, Moaddeli D, Tsui CK, Castro Torres T, Alcala A, Moehle EA, Hoang S, Shalem O, Adams PD, Thorwald MA, Higuchi-Sanabria R. Garcia G, et al. Among authors: tsui ck. Aging Cell. 2023 Jan;22(1):e13742. doi: 10.1111/acel.13742. Epub 2022 Nov 20. Aging Cell. 2023. PMID: 36404134 Free PMC article.
Lipid homeostasis is essential for a maximal ER stress response.
Garcia G, Zhang H, Moreno S, Tsui CK, Webster BM, Higuchi-Sanabria R, Dillin A. Garcia G, et al. Among authors: tsui ck. Elife. 2023 Jul 25;12:e83884. doi: 10.7554/eLife.83884. Elife. 2023. PMID: 37489956 Free PMC article.
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.
Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC. Haney MS, et al. Among authors: tsui ck. Nat Genet. 2018 Dec;50(12):1716-1727. doi: 10.1038/s41588-018-0254-1. Epub 2018 Nov 5. Nat Genet. 2018. PMID: 30397336 Free PMC article.
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.
Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD. Kramer NJ, et al. Among authors: tsui ck. Nat Genet. 2018 Apr;50(4):603-612. doi: 10.1038/s41588-018-0070-7. Epub 2018 Mar 5. Nat Genet. 2018. PMID: 29507424 Free PMC article.
117 results