Brains and brawn: Stress-induced myokine abates nervous system aging

C Kimberly Tsui; Julian G Dishart; Andrew Dillin

doi:10.1016/j.cmet.2021.05.007

Brains and brawn: Stress-induced myokine abates nervous system aging

Cell Metab. 2021 Jun 1;33(6):1067-1069. doi: 10.1016/j.cmet.2021.05.007.

Authors

C Kimberly Tsui¹, Julian G Dishart², Andrew Dillin³

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
² Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
³ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: dillin@berkeley.edu.

PMID: 34077712
DOI: 10.1016/j.cmet.2021.05.007

Abstract

Skeletal muscle secretes numerous systemic factors, termed myokines, which can regulate homeostasis of distal tissues. In this issue, Rai et al. (2021) identify and characterize a novel myokine, Amyrel, which is secreted under muscle proteasome stress and protects central nervous system health and function by enhancing protein quality control during aging.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain / metabolism
Cytokines* / metabolism
Muscle Proteins / metabolism
Muscle, Skeletal* / metabolism

Substances

Cytokines
Muscle Proteins

Grants and funding

T32 NS095939/NS/NINDS NIH HHS/United States