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Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.
Draffan AG, Frey B, Fraser BH, Pool B, Gannon C, Tyndall EM, Cianci J, Harding M, Lilly M, Hufton R, Halim R, Jahangiri S, Bond S, Jeynes TP, Nguyen VT, Wirth V, Luttick A, Tilmanis D, Pryor M, Porter K, Morton CJ, Lin B, Duan J, Bethell RC, Kukolj G, Simoneau B, Tucker SP. Draffan AG, et al. Among authors: tilmanis d. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4984-8. doi: 10.1016/j.bmcl.2014.09.030. Epub 2014 Sep 21. Bioorg Med Chem Lett. 2014. PMID: 25288185
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
Draffan AG, Frey B, Pool B, Gannon C, Tyndall EM, Lilly M, Francom P, Hufton R, Halim R, Jahangiri S, Bond S, Nguyen VT, Jeynes TP, Wirth V, Luttick A, Tilmanis D, Thomas JD, Pryor M, Porter K, Morton CJ, Lin B, Duan J, Kukolj G, Simoneau B, McKercher G, Lagacé L, Amad M, Bethell RC, Tucker SP. Draffan AG, et al. Among authors: tilmanis d. ACS Med Chem Lett. 2014 Apr 10;5(6):679-84. doi: 10.1021/ml500077j. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944743 Free PMC article.
Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitro.
Tyndall EM, Draffan AG, Frey B, Pool B, Halim R, Jahangiri S, Bond S, Wirth V, Luttick A, Tilmanis D, Thomas J, Porter K, Tucker SP. Tyndall EM, et al. Among authors: tilmanis d. Bioorg Med Chem Lett. 2015 Feb 15;25(4):869-73. doi: 10.1016/j.bmcl.2014.12.069. Epub 2014 Dec 30. Bioorg Med Chem Lett. 2015. PMID: 25592710
Influenza antivirals currently in late-phase clinical trial.
Koszalka P, Tilmanis D, Hurt AC. Koszalka P, et al. Among authors: tilmanis d. Influenza Other Respir Viruses. 2017 May;11(3):240-246. doi: 10.1111/irv.12446. Epub 2017 Feb 28. Influenza Other Respir Viruses. 2017. PMID: 28146320 Free PMC article. Review.
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015.
Hurt AC, Besselaar TG, Daniels RS, Ermetal B, Fry A, Gubareva L, Huang W, Lackenby A, Lee RT, Lo J, Maurer-Stroh S, Nguyen HT, Pereyaslov D, Rebelo-de-Andrade H, Siqueira MM, Takashita E, Tashiro M, Tilmanis D, Wang D, Zhang W, Meijer A. Hurt AC, et al. Among authors: tilmanis d. Antiviral Res. 2016 Aug;132:178-85. doi: 10.1016/j.antiviral.2016.06.001. Epub 2016 Jun 3. Antiviral Res. 2016. PMID: 27265623 Free PMC article. Review.
15 results