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G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
Huang Y, Rafael Guimarães T, Todd N, Ferguson C, Weiss KM, Stauffer FR, McDermott B, Hurtle BT, Saito T, Saido TC, MacDonald ML, Homanics GE, Thathiah A. Huang Y, et al. Among authors: thathiah a. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204828119. doi: 10.1073/pnas.2204828119. Epub 2022 Sep 26. Proc Natl Acad Sci U S A. 2022. PMID: 36161942 Free PMC article.
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.
Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A. Huang Y, et al. Among authors: thathiah a. Sci Transl Med. 2015 Oct 14;7(309):309ra164. doi: 10.1126/scitranslmed.aab3492. Sci Transl Med. 2015. PMID: 26468326
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, Tosi S, Munck S, Salas IH, Annaert W, De Strooper B. Guix FX, et al. Among authors: thathiah a. Mol Neurodegener. 2017 Mar 10;12(1):25. doi: 10.1186/s13024-017-0165-0. Mol Neurodegener. 2017. PMID: 28279219 Free PMC article.
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ. Mann JR, et al. Among authors: thathiah a. Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27. Neuron. 2019. PMID: 30826182 Free PMC article.
β-Arrestin2 arrests the clearance of tau in FTLD.
Thathiah A. Thathiah A. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):6968-6970. doi: 10.1073/pnas.2001455117. Epub 2020 Mar 18. Proc Natl Acad Sci U S A. 2020. PMID: 32188777 Free PMC article. No abstract available.
29 results