Summa V - Search Results

1

Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators.

Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Vittoria Orsale M, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R. Ivanova Bencheva L, et al. Among authors: summa v. Bioorg Med Chem Lett. 2022 Oct 1;73:128904. doi: 10.1016/j.bmcl.2022.128904. Epub 2022 Jul 19. Bioorg Med Chem Lett. 2022. PMID: 35868496

2

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

De Francesco R, Tomei L, Altamura S, Summa V, Migliaccio G. De Francesco R, et al. Among authors: summa v. Antiviral Res. 2003 Mar;58(1):1-16. doi: 10.1016/s0166-3542(03)00028-7. Antiviral Res. 2003. PMID: 12719002 Review.

3

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

4

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.

Pace P, Nizi E, Pacini B, Pesci S, Matassa V, De Francesco R, Altamura S, Summa V. Pace P, et al. Among authors: summa v. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3257-61. doi: 10.1016/j.bmcl.2004.03.087. Bioorg Med Chem Lett. 2004. PMID: 15149686

5

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.

Summa V, Petrocchi A, Matassa VG, Taliani M, Laufer R, De Francesco R, Altamura S, Pace P. Summa V, et al. J Med Chem. 2004 Oct 21;47(22):5336-9. doi: 10.1021/jm0494669. J Med Chem. 2004. PMID: 15481971

6

Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.

Muraglia E, Kinzel OD, Laufer R, Miller MD, Moyer G, Munshi V, Orvieto F, Palumbi MC, Pescatore G, Rowley M, Williams PD, Summa V. Muraglia E, et al. Among authors: summa v. Bioorg Med Chem Lett. 2006 May 15;16(10):2748-52. doi: 10.1016/j.bmcl.2006.02.024. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503141

7

4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.

Summa V, Petrocchi A, Matassa VG, Gardelli C, Muraglia E, Rowley M, Paz OG, Laufer R, Monteagudo E, Pace P. Summa V, et al. J Med Chem. 2006 Nov 16;49(23):6646-9. doi: 10.1021/jm060854f. J Med Chem. 2006. PMID: 17154493

8

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.

Quintavalle M, Sambucini S, Summa V, Orsatti L, Talamo F, De Francesco R, Neddermann P. Quintavalle M, et al. Among authors: summa v. J Biol Chem. 2007 Feb 23;282(8):5536-44. doi: 10.1074/jbc.M610486200. Epub 2006 Dec 13. J Biol Chem. 2007. PMID: 17166835 Free article.

9

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V. Pace P, et al. Among authors: summa v. J Med Chem. 2007 May 3;50(9):2225-39. doi: 10.1021/jm070027u. Epub 2007 Apr 12. J Med Chem. 2007. PMID: 17428043

10

Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.

Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, Pace P, Pescatore G, Poma M, Ferreira Mdel R, Scarpelli R, Homnick CF, Ikemoto N, Alfieri A, Verdirame M, Bonelli F, Paz OG, Taliani M, Monteagudo E, Pesci S, Laufer R, Felock P, Stillmock KA, Hazuda D, Rowley M, Summa V. Gardelli C, et al. Among authors: summa v. J Med Chem. 2007 Oct 4;50(20):4953-75. doi: 10.1021/jm0704705. Epub 2007 Sep 8. J Med Chem. 2007. PMID: 17824681

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