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Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation.
Hayden ER, Chen M, Pasquariello KZ, Gibson AA, Petti JJ, Shen S, Qu J, Ong SS, Chen T, Jin Y, Uddin ME, Huang KM, Paz A, Sparreboom A, Hu S, Sprowl JA. Hayden ER, et al. Among authors: sprowl ja. Clin Cancer Res. 2021 Aug 1;27(15):4301-4310. doi: 10.1158/1078-0432.CCR-21-0023. Epub 2021 Mar 4. Clin Cancer Res. 2021. PMID: 33664059 Free PMC article.
Uptake carriers and oncology drug safety.
Sprowl JA, Sparreboom A. Sprowl JA, et al. Drug Metab Dispos. 2014 Apr;42(4):611-22. doi: 10.1124/dmd.113.055806. Epub 2013 Dec 30. Drug Metab Dispos. 2014. PMID: 24378324 Free PMC article. Review.
Cisplatin-induced renal injury is independently mediated by OCT2 and p53.
Sprowl JA, Lancaster CS, Pabla N, Hermann E, Kosloske AM, Gibson AA, Li L, Zeeh D, Schlatter E, Janke LJ, Ciarimboli G, Sparreboom A. Sprowl JA, et al. Clin Cancer Res. 2014 Aug 1;20(15):4026-35. doi: 10.1158/1078-0432.CCR-14-0319. Epub 2014 Jun 10. Clin Cancer Res. 2014. PMID: 24916697 Free PMC article.
A phosphotyrosine switch regulates organic cation transporters.
Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JHM, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N. Sprowl JA, et al. Nat Commun. 2016 Mar 16;7:10880. doi: 10.1038/ncomms10880. Nat Commun. 2016. PMID: 26979622 Free PMC article.
OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.
Leblanc AF, Sprowl JA, Alberti P, Chiorazzi A, Arnold WD, Gibson AA, Hong KW, Pioso MS, Chen M, Huang KM, Chodisetty V, Costa O, Florea T, de Bruijn P, Mathijssen RH, Reinbolt RE, Lustberg MB, Sucheston-Campbell LE, Cavaletti G, Sparreboom A, Hu S. Leblanc AF, et al. Among authors: sprowl ja. J Clin Invest. 2018 Feb 1;128(2):816-825. doi: 10.1172/JCI96160. Epub 2018 Jan 16. J Clin Invest. 2018. PMID: 29337310 Free PMC article.
Strategies to Reduce Solute Carrier-Mediated Toxicity.
Hu S, Sprowl JA. Hu S, et al. Among authors: sprowl ja. Clin Pharmacol Ther. 2018 Nov;104(5):799-802. doi: 10.1002/cpt.1185. Epub 2018 Sep 4. Clin Pharmacol Ther. 2018. PMID: 30028006
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.
Huang KM, Leblanc AF, Uddin ME, Kim JY, Chen M, Eisenmann ED, Gibson AA, Li Y, Hong KW, DiGiacomo D, Xia SH, Alberti P, Chiorazzi A, Housley SN, Cope TC, Sprowl JA, Wang J, Loprinzi CL, Noonan A, Lustberg MB, Cavaletti G, Pabla N, Hu S, Sparreboom A. Huang KM, et al. Among authors: sprowl ja. J Clin Invest. 2020 Sep 1;130(9):4601-4606. doi: 10.1172/JCI136796. J Clin Invest. 2020. PMID: 32484793 Free PMC article.
30 results