Abstract
Toxicity is among the greatest concerns during clinical use of drugs, and it has been well documented that transporter proteins facilitate such events by regulating drug accumulation. However, an important question is whether strategies could be adopted to diminish such toxicities. Although the field is currently in its infancy, some examples exist demonstrating how mechanistic understanding of the role of transporters in drug disposition can aid in alleviating transporter-mediated toxic effects.
© 2018 American Society for Clinical Pharmacology and Therapeutics.
MeSH terms
-
Animals
-
Biological Transport
-
Drug Interactions
-
Drug-Related Side Effects and Adverse Reactions / etiology
-
Drug-Related Side Effects and Adverse Reactions / genetics
-
Drug-Related Side Effects and Adverse Reactions / metabolism
-
Drug-Related Side Effects and Adverse Reactions / prevention & control*
-
Genotype
-
Humans
-
Membrane Transport Modulators / pharmacology*
-
Membrane Transport Proteins / drug effects*
-
Membrane Transport Proteins / genetics
-
Membrane Transport Proteins / metabolism
-
Pharmaceutical Preparations / metabolism*
-
Pharmacogenomic Variants
-
Phenotype
-
Risk Assessment
Substances
-
Membrane Transport Modulators
-
Membrane Transport Proteins
-
Pharmaceutical Preparations