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Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8.
Tzioras M, Daniels MJD, Davies C, Baxter P, King D, McKay S, Varga B, Popovic K, Hernandez M, Stevenson AJ, Barrington J, Drinkwater E, Borella J, Holloway RK, Tulloch J, Moss J, Latta C, Kandasamy J, Sokol D, Smith C, Miron VE, Káradóttir RT, Hardingham GE, Henstridge CM, Brennan PM, McColl BW, Spires-Jones TL. Tzioras M, et al. Among authors: spires jones tl. Cell Rep Med. 2023 Sep 19;4(9):101175. doi: 10.1016/j.xcrm.2023.101175. Epub 2023 Aug 30. Cell Rep Med. 2023. PMID: 37652017 Free PMC article.
Synaptic resilience is associated with maintained cognition during ageing.
King D, Holt K, Toombs J, He X, Dando O, Okely JA, Tzioras M, Rose J, Gunn C, Correia A, Montero C, McAlister H, Tulloch J, Lamont D, Taylor AM, Harris SE, Redmond P, Cox SR, Henstridge CM, Deary IJ, Smith C, Spires-Jones TL. King D, et al. Alzheimers Dement. 2023 Jun;19(6):2560-2574. doi: 10.1002/alz.12894. Epub 2022 Dec 22. Alzheimers Dement. 2023. PMID: 36547260
Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.
Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sánchez-Aced É, Chang YY, Holt K, McGeachan RI, Rose J, Tulloch J, Wilkins L, Smith C, Andrian T, Belbin O, Pujals S, Horrocks MH, Lleó A, Spires-Jones TL. Colom-Cadena M, et al. Neuron. 2023 Jul 19;111(14):2170-2183.e6. doi: 10.1016/j.neuron.2023.04.020. Epub 2023 May 15. Neuron. 2023. PMID: 37192625 Free article.
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features.
Lorenzini I, Alsop E, Levy J, Gittings LM, Lall D, Rabichow BE, Moore S, Pevey R, Bustos LM, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota TA, Logemann A, Rose J, Almeida S, Gao FB, Marks M, Donnelly CJ, Hutchins E, Hung ST, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron TF, Baloh RH, Van Keuren-Jensen K, Sattler R. Lorenzini I, et al. Front Cell Neurosci. 2023 Jun 6;17:1179796. doi: 10.3389/fncel.2023.1179796. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37346371 Free PMC article.
Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila.
Catterson JH, Minkley L, Aspe S, Judd-Mole S, Moura S, Dyson MC, Rajasingam A, Woodling NS, Atilano ML, Ahmad M, Durrant CS, Spires-Jones TL, Partridge L. Catterson JH, et al. Among authors: spires jones tl. Neurobiol Aging. 2023 Dec;132:154-174. doi: 10.1016/j.neurobiolaging.2023.09.008. Epub 2023 Sep 21. Neurobiol Aging. 2023. PMID: 37837732 Free PMC article.
Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10+16 mutation.
Dando O, McGeachan R, McQueen J, Baxter P, Rockley N, McAlister H, Prasad A, He X, King D, Rose J, Jones PB, Tulloch J, Chandran S, Smith C, Hardingham G, Spires-Jones TL. Dando O, et al. Among authors: spires jones tl. medRxiv [Preprint]. 2024 Apr 12:2024.04.09.24305501. doi: 10.1101/2024.04.09.24305501. medRxiv. 2024. PMID: 38645146 Free PMC article. Preprint.
142 results