Reeling from news that reelin defends the brain against Alzheimer's

Edmond N Mouofo; Tara L Spires-Jones

doi:10.1016/j.xcrm.2023.101111

Reeling from news that reelin defends the brain against Alzheimer's

Cell Rep Med. 2023 Jul 18;4(7):101111. doi: 10.1016/j.xcrm.2023.101111.

Authors

Edmond N Mouofo¹, Tara L Spires-Jones²

Affiliations

¹ Centre for Discovery Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
² Centre for Discovery Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK. Electronic address: tara.spires-jones@ed.ac.uk.

Abstract

In a recent study, Lopera and colleagues investigate a person with extreme resilience to autosomal-dominant familial Alzheimer's disease, which they attribute to a rare variant in the RELN gene encoding reelin.¹.

MeSH terms

Alzheimer Disease* / genetics
Brain / metabolism
Cell Adhesion Molecules, Neuronal / genetics
Cell Adhesion Molecules, Neuronal / metabolism
Extracellular Matrix Proteins* / genetics
Extracellular Matrix Proteins* / metabolism
Humans
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism
Serine Endopeptidases / genetics

Substances

Extracellular Matrix Proteins
Cell Adhesion Molecules, Neuronal
Serine Endopeptidases
Nerve Tissue Proteins