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Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.
Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA. Hong L, et al. Among authors: spies m. Redox Biol. 2023 Oct;66:102856. doi: 10.1016/j.redox.2023.102856. Epub 2023 Aug 19. Redox Biol. 2023. PMID: 37633047 Free PMC article.
Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors.
Bhat DS, Malacaria E, Biagi LD, Razzaghi M, Honda M, Hobbs KF, Hengel SR, Pichierri P, Spies MA, Spies M. Bhat DS, et al. Among authors: spies m, spies ma. NAR Cancer. 2023 May 1;5(2):zcad018. doi: 10.1093/narcan/zcad018. eCollection 2023 Jun. NAR Cancer. 2023. PMID: 37139244 Free PMC article.
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE. Gall-Duncan T, et al. Among authors: spies m. Cell. 2023 Oct 26;186(22):4898-4919.e25. doi: 10.1016/j.cell.2023.09.008. Epub 2023 Oct 11. Cell. 2023. PMID: 37827155
326 results