Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power

Kathryn F Hobbs; Jonah Propp; Nicholas R Vance; Andrew Kalenkiewicz; Katie R Witkin; M Ashley Spies

doi:10.1002/chem.202301621

Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power

Chemistry. 2023 Jul 14;29(40):e202301621. doi: 10.1002/chem.202301621. Epub 2023 Jun 7.

Authors

Kathryn F Hobbs¹, Jonah Propp², Nicholas R Vance², Andrew Kalenkiewicz¹, Katie R Witkin², M Ashley Spies^{1

2}

Affiliations

¹ Biochemistry and Molecular Biology Department, University of Iowa, 51 Newton Road, 4-403 Bowen Science Building, Iowa City, IA, 52242, USA.
² Pharmaceutics and Experimental Therapeutics Department, Medicinal and Natural Products Chemistry Division, University of Iowa, 180 South Grand Avenue, Iowa City, IA, 52242, USA.

PMID: 37285583
DOI: 10.1002/chem.202301621

Abstract

Invited for the cover of this issue is the group of Michael Ashley Spies at the University of Iowa. The image depicts how mapping allosteric structure-activity relationships reveals the nexus between the active site and the remote allosteric pocket. Read the full text of the article at 10.1002/chem.202300872.