Spears RJ - Search Results

1

Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.

Bahou C, Spears RJ, Ramírez Rosales AM, Rochet LNC, Barber LJ, Stankevich KS, Miranda JF, Butcher TC, Kerrigan AM, Lazarov VK, Grey W, Chudasama V, Spicer CD. Bahou C, et al. Among authors: spears rj. Biomacromolecules. 2023 Nov 13;24(11):4646-4652. doi: 10.1021/acs.biomac.3c00290. Epub 2023 Oct 4. Biomacromolecules. 2023. PMID: 37792488 Free PMC article.

2

Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions.

Bahou C, Love EA, Leonard S, Spears RJ, Maruani A, Armour K, Baker JR, Chudasama V. Bahou C, et al. Among authors: spears rj. Bioconjug Chem. 2019 Apr 17;30(4):1048-1054. doi: 10.1021/acs.bioconjchem.9b00174. Epub 2019 Mar 18. Bioconjug Chem. 2019. PMID: 30855134

3

Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.

Bahou C , Spears RJ , Aliev AE , Maruani A , Fernandez M , Javaid F , Szijj PA , Baker JR , Chudasama V . Bahou C , et al. Among authors: spears rj. Chem Commun (Camb). 2019 Dec 5;55(98):14829-14832. doi: 10.1039/c9cc08362f. Chem Commun (Camb). 2019. PMID: 31763648

4

Tyrosine bioconjugation - an emergent alternative.

Szijj PA, Kostadinova KA, Spears RJ, Chudasama V. Szijj PA, et al. Among authors: spears rj. Org Biomol Chem. 2020 Nov 28;18(44):9018-9028. doi: 10.1039/d0ob01912g. Epub 2020 Nov 3. Org Biomol Chem. 2020. PMID: 33141139 Free PMC article.

5

A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability.

Bahou C, Szijj PA, Spears RJ, Wall A, Javaid F, Sattikar A, Love EA, Baker JR, Chudasama V. Bahou C, et al. Among authors: spears rj. Bioconjug Chem. 2021 Apr 21;32(4):672-679. doi: 10.1021/acs.bioconjchem.1c00057. Epub 2021 Mar 12. Bioconjug Chem. 2021. PMID: 33710874 Free PMC article.

6

Cysteine protecting groups: applications in peptide and protein science.

Spears RJ, McMahon C, Chudasama V. Spears RJ, et al. Chem Soc Rev. 2021 Oct 4;50(19):11098-11155. doi: 10.1039/d1cs00271f. Chem Soc Rev. 2021. PMID: 34605832 Review.

7

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.

Spears RJ, McMahon C, Shamsabadi M, Bahou C, Thanasi IA, Rochet LNC, Forte N, Thoreau F, Baker JR, Chudasama V. Spears RJ, et al. Chem Commun (Camb). 2022 Jan 13;58(5):645-648. doi: 10.1039/d1cc03802h. Chem Commun (Camb). 2022. PMID: 34747956

8

Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins.

Spears RJ, Chrzastek A, Yap SY, Karu K, Aliev AE, Baker JR, Chudasama V. Spears RJ, et al. Chem Commun (Camb). 2022 Apr 28;58(35):5359-5362. doi: 10.1039/d2cc01090a. Chem Commun (Camb). 2022. PMID: 35394478

9

Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.

Ahmed N, Spears RJ, Sheppard TD, Chudasama V. Ahmed N, et al. Among authors: spears rj. Chem Sci. 2022 Jun 27;13(29):8626-8633. doi: 10.1039/d2sc01626e. eCollection 2022 Jul 29. Chem Sci. 2022. PMID: 35974756 Free PMC article.

10

Correction: Tyrosine bioconjugation - an emergent alternative.

Szijj PA, Kostadinova KA, Spears RJ, Chudasama V. Szijj PA, et al. Among authors: spears rj. Org Biomol Chem. 2022 Nov 9;20(43):8554-8555. doi: 10.1039/d2ob90141b. Org Biomol Chem. 2022. PMID: 36314381 Free PMC article.

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