Sormanni P - Search Results

1

Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations.

Maritan M, Ambrosetti A, Oberti L, Barbiroli A, Diomede L, Romeo M, Lavatelli F, Sormanni P, Palladini G, Bolognesi M, Merlini G, Ricagno S. Maritan M, et al. Among authors: sormanni p. Amyloid. 2019;26(sup1):105-106. doi: 10.1080/13506129.2019.1583185. Amyloid. 2019. PMID: 31343361 Free article. No abstract available.

2

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.

Camilloni C, Sala BM, Sormanni P, Porcari R, Corazza A, De Rosa M, Zanini S, Barbiroli A, Esposito G, Bolognesi M, Bellotti V, Vendruscolo M, Ricagno S. Camilloni C, et al. Among authors: sormanni p. Sci Rep. 2016 May 6;6:25559. doi: 10.1038/srep25559. Sci Rep. 2016. PMID: 27150430 Free PMC article.

3

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Le Marchand T, de Rosa M, Salvi N, Sala BM, Andreas LB, Barbet-Massin E, Sormanni P, Barbiroli A, Porcari R, Sousa Mota C, de Sanctis D, Bolognesi M, Emsley L, Bellotti V, Blackledge M, Camilloni C, Pintacuda G, Ricagno S. Le Marchand T, et al. Among authors: sormanni p. Nat Commun. 2018 Apr 25;9(1):1658. doi: 10.1038/s41467-018-04078-y. Nat Commun. 2018. PMID: 29695721 Free PMC article.

4

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.

Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S. Achour A, et al. Among authors: sormanni p. FEBS J. 2020 Feb;287(3):546-560. doi: 10.1111/febs.15046. Epub 2019 Aug 28. FEBS J. 2020. PMID: 31420997 Free article.

5

Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.

Maritan M, Romeo M, Oberti L, Sormanni P, Tasaki M, Russo R, Ambrosetti A, Motta P, Rognoni P, Mazzini G, Barbiroli A, Palladini G, Vendruscolo M, Diomede L, Bolognesi M, Merlini G, Lavatelli F, Ricagno S. Maritan M, et al. Among authors: sormanni p. J Mol Biol. 2020 Feb 14;432(4):845-860. doi: 10.1016/j.jmb.2019.12.015. Epub 2019 Dec 24. J Mol Biol. 2020. PMID: 31874151 Free article.

6

Fragment-based computational design of antibodies targeting structured epitopes.

Aguilar Rangel M, Bedwell A, Costanzi E, Taylor RJ, Russo R, Bernardes GJL, Ricagno S, Frydman J, Vendruscolo M, Sormanni P. Aguilar Rangel M, et al. Among authors: sormanni p. Sci Adv. 2022 Nov 11;8(45):eabp9540. doi: 10.1126/sciadv.abp9540. Epub 2022 Nov 11. Sci Adv. 2022. PMID: 36367941 Free PMC article.

7

Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone.

Chen J, Yagi H, Sormanni P, Vendruscolo M, Makabe K, Nakamura T, Goto Y, Kuwajima K. Chen J, et al. Among authors: sormanni p. FEBS Lett. 2012 Apr 24;586(8):1120-7. doi: 10.1016/j.febslet.2012.03.019. Epub 2012 Mar 23. FEBS Lett. 2012. PMID: 22575645 Free article.

8

Subdomain architecture and stability of a giant repeat protein.

Tsytlonok M, Sormanni P, Rowling PJ, Vendruscolo M, Itzhaki LS. Tsytlonok M, et al. Among authors: sormanni p. J Phys Chem B. 2013 Oct 24;117(42):13029-37. doi: 10.1021/jp402360x. Epub 2013 Sep 20. J Phys Chem B. 2013. PMID: 24053231

9

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.

Gianni S, Camilloni C, Giri R, Toto A, Bonetti D, Morrone A, Sormanni P, Brunori M, Vendruscolo M. Gianni S, et al. Among authors: sormanni p. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14141-6. doi: 10.1073/pnas.1405233111. Epub 2014 Sep 16. Proc Natl Acad Sci U S A. 2014. PMID: 25228761 Free PMC article.

10

The CamSol method of rational design of protein mutants with enhanced solubility.

Sormanni P, Aprile FA, Vendruscolo M. Sormanni P, et al. J Mol Biol. 2015 Jan 30;427(2):478-90. doi: 10.1016/j.jmb.2014.09.026. Epub 2014 Oct 14. J Mol Biol. 2015. PMID: 25451785

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