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Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference.
Bioorg Med Chem. 2008 Jan 1;16(1):518-29. doi: 10.1016/j.bmc.2007.09.019. Epub 2007 Sep 15.
Bioorg Med Chem. 2008.
PMID: 17904849
Preparation of zwitterionic ribonucleoside phosphoramidites for solid-phase siRNA synthesis.
Smicius R, Engels JW.
Smicius R, et al.
J Org Chem. 2008 Jul 4;73(13):4994-5002. doi: 10.1021/jo800451m. Epub 2008 Jun 4.
J Org Chem. 2008.
PMID: 18522425
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Chemical synthesis of 2'-O-alkylated siRNAs.
Engels JW, Odadzic D, Smicius R, Haas J.
Engels JW, et al. Among authors: smicius r.
Methods Mol Biol. 2010;623:155-70. doi: 10.1007/978-1-60761-588-0_10.
Methods Mol Biol. 2010.
PMID: 20217550
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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J.
Bramsen JB, et al. Among authors: smicius r.
Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12.
Nucleic Acids Res. 2009.
PMID: 19282453
Free PMC article.
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A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J.
Bramsen JB, et al. Among authors: smicius r.
Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7.
Nucleic Acids Res. 2010.
PMID: 20453030
Free PMC article.
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Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G-U wobble base pairs.
Rozners E, Smicius R, Uchiyama C.
Rozners E, et al. Among authors: smicius r.
Chem Commun (Camb). 2005 Dec 14;(46):5778-80. doi: 10.1039/b510846b. Epub 2005 Oct 20.
Chem Commun (Camb). 2005.
PMID: 16307143
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Synthesis and anti-inflammatory activity of derivatives of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones.
Burbuliene MM, Jakubkiene V, Mekuskiene G, Udrenaite E, Smicius R, Vainilavicius P.
Burbuliene MM, et al. Among authors: smicius r.
Farmaco. 2004 Oct;59(10):767-74. doi: 10.1016/j.farmac.2004.05.007.
Farmaco. 2004.
PMID: 15474053
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