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Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.
Ottria A, Zimmermann M, Paardekooper LM, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, Affandi AJ, Chouri E, V D Kroef M, Tieland RG, Bekker CPJ, Wichers CGK, Rossato M, Mocholi-Gimeno E, Tekstra J, Ton E, van Laar JM, Cossu M, Beretta L, Garcia Perez S, Pandit A, Bonte-Mineur F, Reedquist KA, van den Bogaart G, Radstake TRDJ, Marut W. Ottria A, et al. Rheumatology (Oxford). 2022 May 30;61(6):2682-2693. doi: 10.1093/rheumatology/keab532. Rheumatology (Oxford). 2022. PMID: 34559222
Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome.
van der Kroef M, van den Hoogen LL, Mertens JS, Blokland SLM, Haskett S, Devaprasad A, Carvalheiro T, Chouri E, Vazirpanah N, Cossu M, Wichers CGK, Silva-Cardoso SC, Affandi AJ, Bekker CPJ, Lopes AP, Hillen MR, Bonte-Mineur F, Kok MR, Beretta L, Rossato M, Mingueneau M, van Roon JAG, Radstake TRDJ. van der Kroef M, et al. Among authors: silva cardoso sc. Eur J Immunol. 2020 Jan;50(1):119-129. doi: 10.1002/eji.201948129. Epub 2019 Sep 11. Eur J Immunol. 2020. PMID: 31424086 Free article.
Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting.
van der Kroef M, Castellucci M, Mokry M, Cossu M, Garonzi M, Bossini-Castillo LM, Chouri E, Wichers CGK, Beretta L, Trombetta E, Silva-Cardoso S, Vazirpanah N, Carvalheiro T, Angiolilli C, Bekker CPJ, Affandi AJ, Reedquist KA, Bonte-Mineur F, Zirkzee EJM, Bazzoni F, Radstake TRDJ, Rossato M. van der Kroef M, et al. Ann Rheum Dis. 2019 Apr;78(4):529-538. doi: 10.1136/annrheumdis-2018-214295. Epub 2019 Feb 6. Ann Rheum Dis. 2019. PMID: 30793699
Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis.
Chouri E, Wang M, Hillen MR, Angiolilli C, Silva-Cardoso SC, Wichers CGK, van der Kroef M, Bekker CPJ, Cossu M, van Bon L, Affandi AJ, Carvalheiro T, Pandit A, van Roon JAG, Beretta L, Burgering BMT, Radstake TRDJ, Rossato M. Chouri E, et al. Among authors: silva cardoso sc. J Clin Med. 2021 Jan 30;10(3):491. doi: 10.3390/jcm10030491. J Clin Med. 2021. PMID: 33573268 Free PMC article.
Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.
Vincken NLA, Welsing PMJ, Silva-Cardoso SC, Bekker CPJ, Lopes AP, Olde Nordkamp M, Leijten EFA, Radstake TRDJ, Angiolilli C. Vincken NLA, et al. Among authors: silva cardoso sc. Exp Dermatol. 2022 Jun;31(6):962-969. doi: 10.1111/exd.14566. Epub 2022 Mar 21. Exp Dermatol. 2022. PMID: 35297512 Free PMC article.
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