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Oncogenic CDK13 mutations impede nuclear RNA surveillance.
Insco ML, Abraham BJ, Dubbury SJ, Kaltheuner IH, Dust S, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, Esgdaille DE, Henriques T, Brown KM, Chanock SJ, Geyer M, Adelman K, Sharp PA, Young RA, Boutz PL, Zon LI. Insco ML, et al. Among authors: sharp pa. Science. 2023 Apr 21;380(6642):eabn7625. doi: 10.1126/science.abn7625. Epub 2023 Apr 21. Science. 2023. PMID: 37079685 Free PMC article.
Transcription factor trapping by RNA in gene regulatory elements.
Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA. Sigova AA, et al. Among authors: sharp pa. Science. 2015 Nov 20;350(6263):978-81. doi: 10.1126/science.aad3346. Epub 2015 Oct 29. Science. 2015. PMID: 26516199 Free PMC article.
Coactivator condensation at super-enhancers links phase separation and gene control.
Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA. Sabari BR, et al. Among authors: sharp pa. Science. 2018 Jul 27;361(6400):eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21. Science. 2018. PMID: 29930091 Free PMC article.
Divergent transcription from active promoters.
Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA. Seila AC, et al. Among authors: sharp pa. Science. 2008 Dec 19;322(5909):1849-51. doi: 10.1126/science.1162253. Epub 2008 Dec 4. Science. 2008. PMID: 19056940 Free PMC article.
506 results