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The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53.
Piqué-Borràs MR, Jevtic Z, Bagger FO, Seguin J, Sivalingam R, Bezerra MF, Louwagie A, Juge S, Nellas I, Ivanek R, Tzankov A, Moll UM, Cantillo O, Schulz-Heddergott R, Fagnan A, Mercher T, Schwaller J. Piqué-Borràs MR, et al. Among authors: schwaller j. Blood. 2023 May 4;141(18):2245-2260. doi: 10.1182/blood.2022017273. Blood. 2023. PMID: 36735909 Free PMC article.
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S. Fedorov O, et al. Among authors: schwaller j. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. doi: 10.1073/pnas.0708800104. Epub 2007 Dec 11. Proc Natl Acad Sci U S A. 2007. PMID: 18077363 Free PMC article.
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.
Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S, Pogacic V, Villa A, Ehret S, Berridge G, Spoo A, Dierks C, Biondi A, Knapp S, Duyster J, Schwaller J. Grundler R, et al. Among authors: schwaller j. J Exp Med. 2009 Aug 31;206(9):1957-70. doi: 10.1084/jem.20082074. Epub 2009 Aug 17. J Exp Med. 2009. PMID: 19687226 Free PMC article.
PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1).
Decker S, Finter J, Forde AJ, Kissel S, Schwaller J, Mack TS, Kuhn A, Gray N, Follo M, Jumaa H, Burger M, Zirlik K, Pfeifer D, Miduturu CV, Eibel H, Veelken H, Dierks C. Decker S, et al. Among authors: schwaller j. Mol Cancer Ther. 2014 May;13(5):1231-45. doi: 10.1158/1535-7163.MCT-13-0575-T. Epub 2014 Mar 21. Mol Cancer Ther. 2014. PMID: 24659821
116 results