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Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo.
Maihöfer J, Madry H, Rey-Rico A, Venkatesan JK, Goebel L, Schmitt G, Speicher-Mentges S, Cai X, Meng W, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Maihöfer J, et al. Among authors: schmitt g. Adv Mater. 2021 Apr;33(16):e2008451. doi: 10.1002/adma.202008451. Epub 2021 Mar 18. Adv Mater. 2021. PMID: 33734514
rAAV-Mediated sox9 Overexpression Improves the Repair of Osteochondral Defects in a Clinically Relevant Large Animal Model Over Time In Vivo and Reduces Perifocal Osteoarthritic Changes.
Lange C, Madry H, Venkatesan JK, Schmitt G, Speicher-Mentges S, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Lange C, et al. Among authors: schmitt g. Am J Sports Med. 2021 Nov;49(13):3696-3707. doi: 10.1177/03635465211049414. Epub 2021 Oct 13. Am J Sports Med. 2021. PMID: 34643471
In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.
Schrenker S, Cucchiarini M, Goebel L, Oláh T, Venkatesan JK, Schmitt G, Speicher-Mentges S, Maihöfer J, Gao L, Zurakowski D, Menger MD, Laschke MW, Madry H. Schrenker S, et al. Among authors: schmitt g. Osteoarthritis Cartilage. 2023 Apr;31(4):467-481. doi: 10.1016/j.joca.2022.11.010. Epub 2022 Dec 5. Osteoarthritis Cartilage. 2023. PMID: 36481450 Free article.
Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.
Weimer A, Madry H, Venkatesan JK, Schmitt G, Frisch J, Wezel A, Jung J, Kohn D, Terwilliger EF, Trippel SB, Cucchiarini M. Weimer A, et al. Among authors: schmitt g. Mol Med. 2012 May 9;18(1):346-58. doi: 10.2119/molmed.2011.00371. Mol Med. 2012. PMID: 22160392 Free PMC article.
543 results