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Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.
Goodwin LO, Splinter E, Davis TL, Urban R, He H, Braun RE, Chesler EJ, Kumar V, van Min M, Ndukum J, Philip VM, Reinholdt LG, Svenson K, White JK, Sasner M, Lutz C, Murray SA. Goodwin LO, et al. Among authors: sasner m. Genome Res. 2019 Mar;29(3):494-505. doi: 10.1101/gr.233866.117. Epub 2019 Jan 18. Genome Res. 2019. PMID: 30659012 Free PMC article.
Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology.
Kotredes KP, Pandey RS, Persohn S, Elderidge K, Burton CP, Miner EW, Haynes KA, Santos DFS, Williams SP, Heaton N, Ingraham CM, Lloyd C, Garceau D, O'Rourke R, Herrick S, Rangel-Barajas C, Maharjan S, Wang N, Sasner M, Lamb BT, Territo PR, Sukoff Rizzo SJ, Carter GW, Howell GR, Oblak AL. Kotredes KP, et al. Among authors: sasner m. bioRxiv [Preprint]. 2023 Dec 20:2023.12.19.571985. doi: 10.1101/2023.12.19.571985. bioRxiv. 2023. PMID: 38187716 Free PMC article. Preprint.
In vivo validation of late-onset Alzheimer's disease genetic risk factors.
Sasner M, Preuss C, Pandey RS, Uyar A, Garceau D, Kotredes KP, Williams H, Oblak AL, Lin PB, Perkins B, Soni D, Ingraham C, Lee-Gosselin A, Lamb BT, Howell GR, Carter GW. Sasner M, et al. bioRxiv [Preprint]. 2023 Dec 24:2023.12.21.572849. doi: 10.1101/2023.12.21.572849. bioRxiv. 2023. PMID: 38187758 Free PMC article. Preprint.
Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease.
Pandey RS, Arnold M, Batra R, Krumsiek J, Kotredes KP, Garceau D, Williams H, Sasner M, Howell GR, Kaddurah-Daouk R, Carter GW. Pandey RS, et al. Among authors: sasner m. bioRxiv [Preprint]. 2023 Dec 22:2023.12.22.573059. doi: 10.1101/2023.12.22.573059. bioRxiv. 2023. PMID: 38187571 Free PMC article. Updated. Preprint.
A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.
Wang X, Philip VM, Ananda G, White CC, Malhotra A, Michalski PJ, Karuturi KRM, Chintalapudi SR, Acklin C, Sasner M, Bennett DA, De Jager PL, Howell GR, Carter GW. Wang X, et al. Among authors: sasner m. Genetics. 2018 May;209(1):51-64. doi: 10.1534/genetics.117.300673. Epub 2018 Mar 5. Genetics. 2018. PMID: 29507048 Free PMC article.
Toward more predictive genetic mouse models of Alzheimer's disease.
Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M. Onos KD, et al. Among authors: sasner m. Brain Res Bull. 2016 Apr;122:1-11. doi: 10.1016/j.brainresbull.2015.12.003. Epub 2015 Dec 17. Brain Res Bull. 2016. PMID: 26708939 Free PMC article. Review.
Improving mouse models for the study of Alzheimer's disease.
Reagan AM, Onos KD, Heuer SE, Sasner M, Howell GR. Reagan AM, et al. Among authors: sasner m. Curr Top Dev Biol. 2022;148:79-113. doi: 10.1016/bs.ctdb.2021.12.005. Epub 2022 Mar 31. Curr Top Dev Biol. 2022. PMID: 35461569
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE. Xia D, et al. Among authors: sasner m. Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. Mol Neurodegener. 2022. PMID: 35690868 Free PMC article.
Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.
Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope ZA, Little GJ, Williams SG, Ash C, Bleckert A, Ragan T, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Howell GR, Sasner M, Lamb BT. Oblak AL, et al. Among authors: sasner m. Front Aging Neurosci. 2021 Jul 23;13:713726. doi: 10.3389/fnagi.2021.713726. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34366832 Free PMC article.
35 results