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Gefitinib (Iressa) inhibits the CYP3A4-mediated formation of 7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin but activates that of 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]carbonyloxycamptothecin from irinotecan.
Fujita K, Ando Y, Narabayashi M, Miya T, Nagashima F, Yamamoto W, Kodama K, Araki K, Endo H, Sasaki Y. Fujita K, et al. Among authors: sasaki y. Drug Metab Dispos. 2005 Dec;33(12):1785-90. doi: 10.1124/dmd.105.006205. Epub 2005 Aug 25. Drug Metab Dispos. 2005. PMID: 16123050
Novel single nucleotide polymorphism of UGT1A7 gene in Japanese.
Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y. Fujita K, et al. Among authors: sasaki y. Drug Metab Pharmacokinet. 2006 Feb;21(1):75-8. doi: 10.2133/dmpk.21.75. Drug Metab Pharmacokinet. 2006. PMID: 16547397 Free article.
Novel single nucleotide polymorphism of UGT1A9 gene in Japanese.
Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y. Fujita K, et al. Among authors: sasaki y. Drug Metab Pharmacokinet. 2006 Feb;21(1):79-81. doi: 10.2133/dmpk.21.79. Drug Metab Pharmacokinet. 2006. PMID: 16547398 Free article.
Re: UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters.
Ichikawa W, Araki K, Fujita K, Yamamoto W, Endo H, Nagashima F, Tanaka R, Miya T, Kodama K, Sunakawa Y, Narabayashi M, Ando Y, Akiyama Y, Kawara K, Sasaki Y. Ichikawa W, et al. Among authors: sasaki y. J Natl Cancer Inst. 2008 Feb 6;100(3):224-5; author reply 225. doi: 10.1093/jnci/djm302. Epub 2008 Jan 29. J Natl Cancer Inst. 2008. PMID: 18230796 No abstract available.
Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).
Fujita K, Nagashima F, Yamamoto W, Endo H, Sunakawa Y, Yamashita K, Ishida H, Mizuno K, Matsunaga M, Araki K, Tanaka R, Ichikawa W, Miya T, Narabayashi M, Akiyama Y, Kawara K, Ando Y, Sasaki Y. Fujita K, et al. Among authors: sasaki y. Biol Pharm Bull. 2008 Nov;31(11):2137-42. doi: 10.1248/bpb.31.2137. Biol Pharm Bull. 2008. PMID: 18981587 Free article. Clinical Trial.
6,021 results