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Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade.
Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, Pearce OMT, Pearce EL, Bertozzi CR, Zippelius A, Läubli H. Stanczak MA, et al. Among authors: sanin de. Sci Transl Med. 2022 Nov 2;14(669):eabj1270. doi: 10.1126/scitranslmed.abj1270. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322632 Free PMC article.
Alternatively Activated Mononuclear Phagocytes from the Skin Site of Infection and the Impact of IL-4Rα Signalling on CD4+T Cell Survival in Draining Lymph Nodes after Repeated Exposure to Schistosoma mansoni Cercariae.
Prendergast CT, Sanin DE, Mountford AP. Prendergast CT, et al. Among authors: sanin de. PLoS Negl Trop Dis. 2016 Aug 9;10(8):e0004911. doi: 10.1371/journal.pntd.0004911. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27505056 Free PMC article.
Metabolic interventions in the immune response to cancer.
O'Sullivan D, Sanin DE, Pearce EJ, Pearce EL. O'Sullivan D, et al. Among authors: sanin de. Nat Rev Immunol. 2019 May;19(5):324-335. doi: 10.1038/s41577-019-0140-9. Nat Rev Immunol. 2019. PMID: 30820043 Review.
Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function.
Field CS, Baixauli F, Kyle RL, Puleston DJ, Cameron AM, Sanin DE, Hippen KL, Loschi M, Thangavelu G, Corrado M, Edwards-Hicks J, Grzes KM, Pearce EJ, Blazar BR, Pearce EL. Field CS, et al. Among authors: sanin de. Cell Metab. 2020 Feb 4;31(2):422-437.e5. doi: 10.1016/j.cmet.2019.11.021. Epub 2019 Dec 26. Cell Metab. 2020. PMID: 31883840 Free PMC article.
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy.
Klein Geltink RI, Edwards-Hicks J, Apostolova P, O'Sullivan D, Sanin DE, Patterson AE, Puleston DJ, Ligthart NAM, Buescher JM, Grzes KM, Kabat AM, Stanczak M, Curtis JD, Hässler F, Uhl FM, Fabri M, Zeiser R, Pearce EJ, Pearce EL. Klein Geltink RI, et al. Among authors: sanin de. Nat Metab. 2020 Aug;2(8):703-716. doi: 10.1038/s42255-020-0256-z. Epub 2020 Aug 3. Nat Metab. 2020. PMID: 32747793 Free PMC article.
Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity.
Corrado M, Edwards-Hicks J, Villa M, Flachsmann LJ, Sanin DE, Jacobs M, Baixauli F, Stanczak M, Anderson E, Azuma M, Quintana A, Curtis JD, Clapes T, Grzes KM, Kabat AM, Kyle R, Patterson AE, Geltink RK, Amulic B, Steward CG, Strathdee D, Trompouki E, O'Sullivan D, Pearce EJ, Pearce EL. Corrado M, et al. Among authors: sanin de. Cell Metab. 2020 Dec 1;32(6):981-995.e7. doi: 10.1016/j.cmet.2020.11.003. Cell Metab. 2020. PMID: 33264603 Free PMC article.
45 results