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Osteoarthritis and obesity: experimental models.
Gabay O, Hall DJ, Berenbaum F, Henrotin Y, Sanchez C. Gabay O, et al. Among authors: sanchez c. Joint Bone Spine. 2008 Dec;75(6):675-9. doi: 10.1016/j.jbspin.2008.07.011. Epub 2008 Nov 20. Joint Bone Spine. 2008. PMID: 19022697 Free PMC article. Review.
Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.
Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Sanchez C, et al. Osteoarthritis Cartilage. 2005 Nov;13(11):979-87. doi: 10.1016/j.joca.2005.03.008. Osteoarthritis Cartilage. 2005. PMID: 16243232 Free article.
2,983 results