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C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein.
Gargantilla M, Francés C, Adhav A, Forcada-Nadal A, Martínez-Gualda B, Martí-Marí O, López-Redondo ML, Melero R, Marco-Marín C, Gougeard N, Espinosa C, Rubio-Del-Campo A, Ruiz-Partida R, Hernández-Sierra MDP, Villamayor-Belinchón L, Bravo J, Llacer JL, Marina A, Rubio V, San-Félix A, Geller R, Pérez-Pérez MJ. Gargantilla M, et al. Among authors: san felix a. J Med Chem. 2023 Aug 10;66(15):10432-10457. doi: 10.1021/acs.jmedchem.3c00576. Epub 2023 Jul 20. J Med Chem. 2023. PMID: 37471688 Free PMC article.
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (TSAO) pyrimidine nucleosides.
Camarasa MJ, Pérez-Pérez MJ, San-Félix A, Balzarini J, De Clercq E. Camarasa MJ, et al. J Med Chem. 1992 Jul 24;35(15):2721-7. doi: 10.1021/jm00093a002. J Med Chem. 1992. PMID: 1495006
Novel TSAO derivatives modified at positions 3" and 4" of the spiro moiety.
Lobatón E, Velázquez S, San-Félix A, Chamorro C, Tuñón V, Esteban-Gamboa A, De Clercq E, Balzarini J, Camarasa MJ, Pérez-Pérez MJ. Lobatón E, et al. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):675-6. doi: 10.1080/15257779908041536. Nucleosides Nucleotides. 1999. PMID: 10432663
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.
Rodríguez-Barrios F, Pérez C, Lobatón E, Velázquez S, Chamorro C, San-Félix A, Pérez-Pérez MJ, Camarasa MJ, Pelemans H, Balzarini J, Gago F. Rodríguez-Barrios F, et al. J Med Chem. 2001 Jun 7;44(12):1853-65. doi: 10.1021/jm001095i. J Med Chem. 2001. PMID: 11384232
73 results