Abstract
Novel series of [ddN]-(CH2)n-[TSAO-T] heterodimers have been prepared and tested for their anti-HIV-1 and HIV-2 activity. The most active compound of this series was the [d4T]-(CH2)3-[TSAO-T] heterodimer (EC50 = 0.018 +/- 0.03 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Cell Line
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Dimerization
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HIV Reverse Transcriptase / antagonists & inhibitors
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HIV-1 / drug effects
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HIV-1 / enzymology
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Humans
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Reverse Transcriptase Inhibitors / chemistry*
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Reverse Transcriptase Inhibitors / pharmacology*
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Spiro Compounds / chemistry*
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Spiro Compounds / pharmacology*
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Thymidine / analogs & derivatives*
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Thymidine / chemistry
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Thymidine / pharmacology
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Uridine / analogs & derivatives
Substances
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Anti-HIV Agents
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Reverse Transcriptase Inhibitors
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Spiro Compounds
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HIV Reverse Transcriptase
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Thymidine
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TSAO-T
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Uridine