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CinA mediates multidrug tolerance in Mycobacterium tuberculosis.
Kreutzfeldt KM, Jansen RS, Hartman TE, Gouzy A, Wang R, Krieger IV, Zimmerman MD, Gengenbacher M, Sarathy JP, Xie M, Dartois V, Sacchettini JC, Rhee KY, Schnappinger D, Ehrt S. Kreutzfeldt KM, et al. Among authors: sacchettini jc. Nat Commun. 2022 Apr 22;13(1):2203. doi: 10.1038/s41467-022-29832-1. Nat Commun. 2022. PMID: 35459278 Free PMC article.
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Colangeli R, Helb D, Sridharan S, Sun J, Varma-Basil M, Hazbón MH, Harbacheuski R, Megjugorac NJ, Jacobs WR Jr, Holzenburg A, Sacchettini JC, Alland D. Colangeli R, et al. Among authors: sacchettini jc. Mol Microbiol. 2005 Mar;55(6):1829-40. doi: 10.1111/j.1365-2958.2005.04510.x. Mol Microbiol. 2005. PMID: 15752203 Free article.
Mechanism of thioamide drug action against tuberculosis and leprosy.
Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Wang F, et al. Among authors: sacchettini jc. J Exp Med. 2007 Jan 22;204(1):73-8. doi: 10.1084/jem.20062100. Epub 2007 Jan 16. J Exp Med. 2007. PMID: 17227913 Free PMC article.
High throughput crystallography of TB drug targets.
Murillo AC, Li HY, Alber T, Baker EN, Berger JM, Cherney LT, Cherney MM, Cho YS, Eisenberg D, Garen CR, Goulding CW, Hung LW, Ioerger TR, Jacobs WR, James MN, Kim C, Krieger I, Lott JS, Sankaranarayanan R, Segelke BW, Terwilliger TC, Wang F, Wang S, Sacchettini JC. Murillo AC, et al. Among authors: sacchettini jc. Infect Disord Drug Targets. 2007 Jun;7(2):127-39. doi: 10.2174/187152607781001853. Infect Disord Drug Targets. 2007. PMID: 17970224 Review.
346 results