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Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended-release microparticle formulation: A phase 1, dose-ascending study in male volunteers.
Jensen EK, Bøgevig S, Balchen T, Springborg AH, Royal MA, Storgaard IK, Lund TM, Møller K, Werner MU. Jensen EK, et al. Among authors: royal ma. Basic Clin Pharmacol Toxicol. 2024 May;134(5):657-675. doi: 10.1111/bcpt.13998. Epub 2024 Mar 14. Basic Clin Pharmacol Toxicol. 2024. PMID: 38482995 Clinical Trial.
Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19.
Mao L, Shaabani N, Zhang X, Jin C, Xu W, Argent C, Kushnareva Y, Powers C, Stegman K, Liu J, Xie H, Xu C, Bao Y, Xu L, Zhang Y, Yang H, Qian S, Hu Y, Shao J, Zhang C, Li T, Li Y, Liu N, Lin Z, Wang S, Wang C, Shen W, Lin Y, Shu D, Zhu Z, Kotoi O, Kerwin L, Han Q, Chumakova L, Teijaro J, Royal M, Brunswick M, Allen R, Ji H, Lu H, Xu X. Mao L, et al. Among authors: royal m. Med. 2024 Feb 9;5(2):169-171. doi: 10.1016/j.medj.2024.01.013. Med. 2024. PMID: 38340710 Free article. No abstract available.
Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19.
Mao L, Shaabani N, Zhang X, Jin C, Xu W, Argent C, Kushnareva Y, Powers C, Stegman K, Liu J, Xie H, Xu C, Bao Y, Xu L, Zhang Y, Yang H, Qian S, Hu Y, Shao J, Zhang C, Li T, Li Y, Liu N, Lin Z, Wang S, Wang C, Shen W, Lin Y, Shu D, Zhu Z, Kotoi O, Kerwin L, Han Q, Chumakova L, Teijaro J, Royal M, Brunswick M, Allen R, Ji H, Lu H, Xu X. Mao L, et al. Among authors: royal m. Med. 2024 Jan 12;5(1):42-61.e23. doi: 10.1016/j.medj.2023.12.004. Epub 2024 Jan 4. Med. 2024. PMID: 38181791 Free article.
Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration.
Laranjeiro R, Harinath G, Hewitt JE, Hartman JH, Royal MA, Meyer JN, Vanapalli SA, Driscoll M. Laranjeiro R, et al. Among authors: royal ma. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23829-23839. doi: 10.1073/pnas.1909210116. Epub 2019 Nov 4. Proc Natl Acad Sci U S A. 2019. PMID: 31685639 Free PMC article.
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Lucanic M, et al. Among authors: royal ma. Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256. Nat Commun. 2017. PMID: 28220799 Free PMC article.
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