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A polybromodiphenyl ether from an Indonesian marine sponge Lamellodysidea herbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment.
Yamazaki H, Sumilat DA, Kanno S, Ukai K, Rotinsulu H, Wewengkang DS, Ishikawa M, Mangindaan RE, Namikoshi M. Yamazaki H, et al. Among authors: rotinsulu h. J Nat Med. 2013 Oct;67(4):730-5. doi: 10.1007/s11418-012-0735-y. Epub 2012 Dec 29. J Nat Med. 2013. PMID: 23274914 Free PMC article.
A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.
Maarisit W, Yamazaki H, Kanno SI, Tomizawa A, Rotinsulu H, Wewengkang DS, Sumilat DA, Ukai K, Kapojos MM, Namikoshi M. Maarisit W, et al. Among authors: rotinsulu h. Bioorg Med Chem Lett. 2017 Feb 15;27(4):999-1002. doi: 10.1016/j.bmcl.2016.12.077. Epub 2016 Dec 31. Bioorg Med Chem Lett. 2017. PMID: 28109786
34 results