Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp

J Nat Med. 2018 Jun;72(3):779-783. doi: 10.1007/s11418-018-1193-y. Epub 2018 Mar 5.

Abstract

Cladosporamide A (1), a new protein tyrosine phosphatase (PTP) 1B inhibitor, was isolated together with a known prenylated flavanone derivative (2) from the culture broth of an Indonesian marine sponge-derived Cladosporium sp. TPU1507 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on 1D and 2D NMR data. Compound 1 modestly inhibited PTP1B and T-cell PTP (TCPTP) activities with IC50 values of 48 and 54 μM, respectively. The inhibitory activity of 2 against PTP1B (IC50 = 11 μM) was approximately 2-fold stronger than that against TCPTP (IC50 = 27 μM).

Keywords: Cladosporamide A; Cladosporium sp.; Inhibitor; Marine sponge-derived fungus; Protein tyrosine phosphatase 1B.

MeSH terms

  • Animals
  • Cladosporium / chemistry*
  • Indonesia
  • Porifera / chemistry*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / therapeutic use

Substances

  • Protein Tyrosine Phosphatase, Non-Receptor Type 1