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Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. Bonsor DA, et al. Among authors: rodriguez viciana p. Nat Struct Mol Biol. 2022 Oct;29(10):966-977. doi: 10.1038/s41594-022-00841-4. Epub 2022 Sep 29. Nat Struct Mol Biol. 2022. PMID: 36175670 Free PMC article.
RalGDS comes of age.
Rodriguez-Viciana P, McCormick F. Rodriguez-Viciana P, et al. Cancer Cell. 2005 Mar;7(3):205-6. doi: 10.1016/j.ccr.2005.02.012. Cancer Cell. 2005. PMID: 15766656 Free article.
An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.
Young LC, Hartig N, Muñoz-Alegre M, Oses-Prieto JA, Durdu S, Bender S, Vijayakumar V, Vietri Rudan M, Gewinner C, Henderson S, Jathoul AP, Ghatrora R, Lythgoe MF, Burlingame AL, Rodriguez-Viciana P. Young LC, et al. Among authors: rodriguez viciana p. Mol Cell. 2013 Dec 12;52(5):679-92. doi: 10.1016/j.molcel.2013.10.004. Epub 2013 Nov 7. Mol Cell. 2013. PMID: 24211266 Free article.
SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Boned Del Río I, Young LC, Sari S, Jones GG, Ringham-Terry B, Hartig N, Rejnowicz E, Lei W, Bhamra A, Surinova S, Rodriguez-Viciana P. Boned Del Río I, et al. Among authors: rodriguez viciana p. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13330-13339. doi: 10.1073/pnas.1902658116. Epub 2019 Jun 18. Proc Natl Acad Sci U S A. 2019. PMID: 31213532 Free PMC article.
36 results