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Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.
Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J, Lochner M, Peinelt C, Reymond JL, Abriel H. Ozhathil LC, et al. Among authors: reymond jl. Br J Pharmacol. 2018 Jun;175(12):2504-2519. doi: 10.1111/bph.14220. Epub 2018 Apr 29. Br J Pharmacol. 2018. PMID: 29579323 Free PMC article.
Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
Kilchmann F, Marcaida MJ, Kotak S, Schick T, Boss SD, Awale M, Gönczy P, Reymond JL. Kilchmann F, et al. Among authors: reymond jl. J Med Chem. 2016 Aug 11;59(15):7188-211. doi: 10.1021/acs.jmedchem.6b00709. Epub 2016 Jul 20. J Med Chem. 2016. PMID: 27391133
Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland.
Probst D, Heitz M, Poirier M, Gan BH, Delalande C, Reymond JL. Probst D, et al. Among authors: reymond jl. ChemMedChem. 2017 Oct 9;12(19):1645-1651. doi: 10.1002/cmdc.201700306. Epub 2017 Sep 22. ChemMedChem. 2017. PMID: 28941184
Optimizing TRPM4 inhibitors in the MHFP6 chemical space.
Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch J, Abriel H, Reymond JL. Delalande C, et al. Among authors: reymond jl. Eur J Med Chem. 2019 Mar 15;166:167-177. doi: 10.1016/j.ejmech.2019.01.048. Epub 2019 Jan 24. Eur J Med Chem. 2019. PMID: 30708257
The name tells the story: Two-pore channels.
Stokłosa P, Probst D, Reymond JL, Peinelt C. Stokłosa P, et al. Among authors: reymond jl. Cell Calcium. 2020 Jul;89:102215. doi: 10.1016/j.ceca.2020.102215. Epub 2020 May 11. Cell Calcium. 2020. PMID: 32442744
333 results