The name tells the story: Two-pore channels

Paulina Stokłosa; Daniel Probst; Jean-Louis Reymond; Christine Peinelt

doi:10.1016/j.ceca.2020.102215

The name tells the story: Two-pore channels

Cell Calcium. 2020 Jul:89:102215. doi: 10.1016/j.ceca.2020.102215. Epub 2020 May 11.

Authors

Paulina Stokłosa¹, Daniel Probst², Jean-Louis Reymond², Christine Peinelt³

Affiliations

¹ Institute of Biochemistry and Molecular Medicine, National Center of Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland.
² Department of Chemistry and Biochemistry, National Center of Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland.
³ Institute of Biochemistry and Molecular Medicine, National Center of Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland. Electronic address: christine.peinelt@ibmm.unibe.ch.

PMID: 32442744
DOI: 10.1016/j.ceca.2020.102215

Abstract

TPC2-A1-N and TPC2-A1-P, two novel small molecules, differentially activate two-pore channel 2 (TPC2) and mimic the activation of TPC2 with NAADP and PIP₂, resulting in distinct ion channel selectivities. These two different modes of TPC2 activity have physiological, and possibly pathophysiological, implications as they can modulate vesicle trafficking and lysosomal exocytosis.

Keywords: Agonist; Ion channel selectivity; Lysosomal exocytosis; TMAP; Two-pore channel; Vesicle motility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium Channel Agonists / chemistry
Calcium Channel Agonists / pharmacology
Calcium Channels / metabolism*
Cell Membrane Permeability / drug effects
Humans
Ions
Models, Molecular

Substances

Calcium Channel Agonists
Calcium Channels
Ions