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Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.
Kline T, Xu C, Kreitzer FR, Hurst DP, Eldeeb KM, Wager-Miller J, Olivas K, Hepburn SA, Huffman JW, Mackie K, Howlett AC, Reggio P, Stella N. Kline T, et al. Among authors: reggio p. Eur J Med Chem. 2023 Mar 5;249:115123. doi: 10.1016/j.ejmech.2023.115123. Epub 2023 Jan 26. Eur J Med Chem. 2023. PMID: 36708677 Free PMC article.
Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship.
Figuerola-Asencio L, Morales P, Zhao P, Hurst DP, Sayed SS, Colón KL, Gómez-Cañas M, Fernández-Ruiz J, Croatt MP, Reggio PH, Abood ME, Jagerovic N. Figuerola-Asencio L, et al. Among authors: reggio ph. ACS Med Chem Lett. 2022 Dec 2;14(1):18-25. doi: 10.1021/acsmedchemlett.2c00325. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655130 Free PMC article.
TRPV1 Activation by Anandamide via a Unique Lipid Pathway.
Muller C, Lynch DL, Hurst DP, Reggio PH. Muller C, et al. Among authors: reggio ph. J Chem Inf Model. 2021 Dec 27;61(12):5742-5746. doi: 10.1021/acs.jcim.1c00893. Epub 2021 Nov 15. J Chem Inf Model. 2021. PMID: 34780173
Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.
Garai S, Leo LM, Szczesniak AM, Hurst DP, Schaffer PC, Zagzoog A, Black T, Deschamps JR, Miess E, Schulz S, Janero DR, Straiker A, Pertwee RG, Abood ME, Kelly MEM, Reggio PH, Laprairie RB, Thakur GA. Garai S, et al. Among authors: reggio ph. J Med Chem. 2021 Jun 24;64(12):8104-8126. doi: 10.1021/acs.jmedchem.1c00040. Epub 2021 Apr 7. J Med Chem. 2021. PMID: 33826336
128 results