Abstract
The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Arachidonic Acids / pharmacology
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Cannabinoid Receptor Modulators* / metabolism
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Endocannabinoids*
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Polyunsaturated Alkamides / pharmacology
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Receptor, Cannabinoid, CB1 / metabolism
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TRPV Cation Channels
Substances
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Arachidonic Acids
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Polyunsaturated Alkamides
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Receptor, Cannabinoid, CB1
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TRPV Cation Channels
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anandamide