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Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.
Guirguis AA, Ofir-Rosenfeld Y, Knezevic K, Blackaby W, Hardick D, Chan YC, Motazedian A, Gillespie A, Vassiliadis D, Lam EYN, Tran K, Andrews B, Harbour ME, Vasiliauskaite L, Saunders CJ, Tsagkogeorga G, Azevedo A, Obacz J, Pilka ES, Carkill M, MacPherson L, Wainwright EN, Liddicoat B, Blyth BJ, Albertella MR, Rausch O, Dawson MA. Guirguis AA, et al. Among authors: rausch o. Cancer Discov. 2023 Oct 5;13(10):2228-2247. doi: 10.1158/2159-8290.CD-23-0007. Cancer Discov. 2023. PMID: 37548590
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T. Yankova E, et al. Among authors: rausch o. Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26. Nature. 2021. PMID: 33902106 Free PMC article.
Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning.
Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J, Zarnack K. Körtel N, et al. Among authors: rausch o. Nucleic Acids Res. 2021 Sep 20;49(16):e92. doi: 10.1093/nar/gkab485. Nucleic Acids Res. 2021. PMID: 34157120 Free PMC article.
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals.
Rücklé C, Körtel N, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI, König J. Rücklé C, et al. Among authors: rausch o. Nat Struct Mol Biol. 2023 Aug;30(8):1207-1215. doi: 10.1038/s41594-023-00997-7. Epub 2023 May 18. Nat Struct Mol Biol. 2023. PMID: 37202476 Free PMC article.
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.
Anderson KE, Boyle KB, Davidson K, Chessa TA, Kulkarni S, Jarvis GE, Sindrilaru A, Scharffetter-Kochanek K, Rausch O, Stephens LR, Hawkins PT. Anderson KE, et al. Among authors: rausch o. Blood. 2008 Dec 15;112(13):5202-11. doi: 10.1182/blood-2008-04-149450. Epub 2008 Aug 28. Blood. 2008. PMID: 18755982 Free article.
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages.
Sturgess K, Yankova E, Vijayabaskar MS, Isobe T, Rak J, Kucinski I, Barile M, Webster NA, Eleftheriou M, Hannah R, Gozdecka M, Vassiliou G, Rausch O, Wilson NK, Göttgens B, Tzelepis K. Sturgess K, et al. Among authors: rausch o. Leukemia. 2023 Oct;37(10):2133-2137. doi: 10.1038/s41375-023-01965-2. Epub 2023 Jul 19. Leukemia. 2023. PMID: 37464070 Free PMC article. No abstract available.
Author Correction: RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals.
Rücklé C, Körtel N, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI, König J. Rücklé C, et al. Among authors: rausch o. Nat Struct Mol Biol. 2023 Oct;30(10):1607. doi: 10.1038/s41594-023-01053-0. Nat Struct Mol Biol. 2023. PMID: 37415011 Free PMC article. No abstract available.
Light Sheet Microscopy Using FITC-Albumin Followed by Immunohistochemistry of the Same Rehydrated Brains Reveals Ischemic Brain Injury and Early Microvascular Remodeling.
Mohamud Yusuf A, Hagemann N, Schulten S, Rausch O, Wagner K, Hussner T, Qi Y, Totzeck M, Kleinschnitz C, Squire A, Gunzer M, Hermann DM. Mohamud Yusuf A, et al. Among authors: rausch o. Front Cell Neurosci. 2021 Jan 5;14:625513. doi: 10.3389/fncel.2020.625513. eCollection 2020. Front Cell Neurosci. 2021. PMID: 33469420 Free PMC article.
29 results