Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages

Katherine Sturgess; Eliza Yankova; M S Vijayabaskar; Tomoya Isobe; Justyna Rak; Iwo Kucinski; Melania Barile; Natalie A Webster; Maria Eleftheriou; Rebecca Hannah; Malgorzata Gozdecka; George Vassiliou; Oliver Rausch; Nicola K Wilson; Berthold Göttgens; Konstantinos Tzelepis

doi:10.1038/s41375-023-01965-2

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages

Leukemia. 2023 Oct;37(10):2133-2137. doi: 10.1038/s41375-023-01965-2. Epub 2023 Jul 19.

Authors

Katherine Sturgess^{1

2}, Eliza Yankova^{1

2

3}, M S Vijayabaskar^{1

2}, Tomoya Isobe^{1

2}, Justyna Rak^{1

2}, Iwo Kucinski^{1

2}, Melania Barile^{1

2}, Natalie A Webster⁴, Maria Eleftheriou^{1

2

3}, Rebecca Hannah^{1

2}, Malgorzata Gozdecka^{1

2}, George Vassiliou^{1

2}, Oliver Rausch⁴, Nicola K Wilson^{1

2}, Berthold Göttgens^{5

6}, Konstantinos Tzelepis^{7

8

9

10}

Affiliations

¹ Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, UK.
² Department of Haematology, University of Cambridge, Cambridge, CB2 0AW, UK.
³ Milner Therapeutics Institute, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.
⁴ Storm Therapeutics Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK.
⁵ Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, UK. bg200@cam.ac.uk.
⁶ Department of Haematology, University of Cambridge, Cambridge, CB2 0AW, UK. bg200@cam.ac.uk.
⁷ Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AW, UK. kt404@cam.ac.uk.
⁸ Department of Haematology, University of Cambridge, Cambridge, CB2 0AW, UK. kt404@cam.ac.uk.
⁹ Milner Therapeutics Institute, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK. kt404@cam.ac.uk.
¹⁰ Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. kt404@cam.ac.uk.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hematopoietic System*
Humans
Methyltransferases* / genetics

Substances

Methyltransferases
METTL3 protein, human

Publication types

MeSH terms

Substances

Grants and funding