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Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.
Purushottamachar P, Godbole AM, Gediya LK, Martin MS, Vasaitis TS, Kwegyir-Afful AK, Ramalingam S, Ates-Alagoz Z, Njar VC. Purushottamachar P, et al. Among authors: ramalingam s. J Med Chem. 2013 Jun 27;56(12):4880-98. doi: 10.1021/jm400048v. Epub 2013 Jun 7. J Med Chem. 2013. PMID: 23713567 Free PMC article.
VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.
Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC. Godbole AM, et al. Among authors: ramalingam s. Eur J Pharmacol. 2014 Jul 5;734:98-104. doi: 10.1016/j.ejphar.2014.04.004. Epub 2014 Apr 12. Eur J Pharmacol. 2014. PMID: 24726842 Free PMC article.
Novel C-4 heteroaryl 13-cis-retinamide Mnk/AR degrading agents inhibit cell proliferation and migration and induce apoptosis in human breast and prostate cancer cells and suppress growth of MDA-MB-231 human breast and CWR22Rv1 human prostate tumor xenografts in mice.
Mbatia HW, Ramalingam S, Ramamurthy VP, Martin MS, Kwegyir-Afful AK, Njar VC. Mbatia HW, et al. Among authors: ramalingam s. J Med Chem. 2015 Feb 26;58(4):1900-14. doi: 10.1021/jm501792c. Epub 2015 Feb 12. J Med Chem. 2015. PMID: 25634130 Free PMC article.
1,078 results