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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. Pao PC, et al. Among authors: raju rm. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120. doi: 10.1073/pnas.2217864120. Epub 2023 Apr 12. Proc Natl Acad Sci U S A. 2023. PMID: 37043533 Free PMC article.
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERS, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G, Mousa GA, Wong MY, Ye P, Nagiri RK, Lo I, Holtzman J, Corona C, Yarahmady A, Gill MT, Raju RM, Mok SA, Gong S, Luo W, Zhao M, Tracy TE, Ratan RR, Tsai LH, Sinha SC, Gan L. Udeochu JC, et al. Among authors: raju rm. Nat Neurosci. 2023 May;26(5):737-750. doi: 10.1038/s41593-023-01315-6. Epub 2023 Apr 24. Nat Neurosci. 2023. PMID: 37095396 Free PMC article.
Microbial modulation via cross-fostering prevents the effects of pervasive environmental stressors on microglia and social behavior, but not the dopamine system.
Smith CJ, Rendina DN, Kingsbury MA, Malacon KE, Nguyen DM, Tran JJ, Devlin BA, Raju RM, Clark MJ, Burgett L, Zhang JH, Cetinbas M, Sadreyev RI, Chen K, Iyer MS, Bilbo SD. Smith CJ, et al. Among authors: raju rm. Mol Psychiatry. 2023 Jun;28(6):2549-2562. doi: 10.1038/s41380-023-02108-w. Epub 2023 May 17. Mol Psychiatry. 2023. PMID: 37198262 Free PMC article.
Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson's Disease.
Prabhakaran P, Nadig A, M S, Tuladhar S, Raju RM, Chidambaram SB, Kempaiah BB, Raghavendra NM, Kumar Br P. Prabhakaran P, et al. Among authors: raju rm. ACS Omega. 2023 Feb 10;8(7):6825-6837. doi: 10.1021/acsomega.2c07521. eCollection 2023 Feb 21. ACS Omega. 2023. PMID: 36844520 Free PMC article.
MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration.
Barker SJ, Raju RM, Milman NEP, Wang J, Davila-Velderrain J, Gunter-Rahman F, Parro CC, Bozzelli PL, Abdurrob F, Abdelaal K, Bennett DA, Kellis M, Tsai LH. Barker SJ, et al. Among authors: raju rm. Sci Transl Med. 2021 Nov 3;13(618):eabd7695. doi: 10.1126/scitranslmed.abd7695. Epub 2021 Nov 3. Sci Transl Med. 2021. PMID: 34731014 Free PMC article.
26 results