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Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068.
J Med Chem. 2008.
PMID: 18800759
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA.
Wlodek A, et al. Among authors: radzom m.
Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3.
Nat Commun. 2017.
PMID: 29089518
Free PMC article.
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Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite.
Höfer I, Crüsemann M, Radzom M, Geers B, Flachshaar D, Cai X, Zeeck A, Piel J.
Höfer I, et al. Among authors: radzom m.
Chem Biol. 2011 Mar 25;18(3):381-91. doi: 10.1016/j.chembiol.2010.12.018.
Chem Biol. 2011.
PMID: 21439483
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Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium.
Reinscheid UM, Farjon J, Radzom M, Haberz P, Zeeck A, Blackledge M, Griesinger C.
Reinscheid UM, et al. Among authors: radzom m.
Chembiochem. 2006 Feb;7(2):287-96. doi: 10.1002/cbic.200500277.
Chembiochem. 2006.
PMID: 16416488
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Fogacin, a novel cyclic octaketide produced by Streptomyces strain Tü 6319.
Radzom M, Zeeck A, Antal N, Fiedler HP.
Radzom M, et al.
J Antibiot (Tokyo). 2006 May;59(5):315-7. doi: 10.1038/ja.2006.45.
J Antibiot (Tokyo). 2006.
PMID: 16883783
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