Abstract
A new octaketide named fogacin (1) was isolated from Streptomyces sp. (strain Tü 6319). Furthermore two shunt metabolites, SEK4b (2) and anhydroSEK4b (3), were detected and identified as non-enzymatically cyclized products of polyketide intermediates built during the biosynthesis of actinorhodin. SEK4b (2) as well as anhydroSEK4b (3) were previously described as metabolites of genetically engineered strains.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Circular Dichroism
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Macrolides / chemistry*
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Macrolides / isolation & purification
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Macrolides / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Streptomyces / chemistry*
Substances
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Anti-Bacterial Agents
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Macrolides